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Article

Targeting BACH1 by HPPE inhibits the Wnt/β-catenin pathway and malignant phenotype in glioblastoma cells.

Apoptosis : an international journal on programmed cell death - 1 Dec 2025

Wang Yuzhu, Yang Changxiao, Guo Li, Nie Peiyu, Hu Xiaowei, Zhou Hongfeng, Li Huibo, Tao Haiquan, Wu Jin

Abstract excerpt

BTB domain and CNC homology 1 (BACH1) has been reported to be a vital regulator of tumor progression. However, methods for targeting BACH1 in cancers have not been fully researched. In this study, we identified BACH1 as a poor prognosis-related factor in patients with GBM. Furthermore, a small-molecule compound, HPPE, was found to interact with BACH1 and inhibit the progression of GBM in vitro and in vivo....

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Identifiers

PMID: 40956552
DOI: 10.1007/s10495-025-02183-0

Genes

BACH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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