Article
Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling.
Oncogene - 17 Apr 2008
Zhu J-H, Chen R, Yi W, Cantin G T, Fearns C, Yang Y, Yates J R, Lee J-D
Abstract excerpt
Deregulated Her2/ErbB2 receptor tyrosine kinase drives tumorigenesis and tumor progression in a variety of human tissues. Her2 transmits oncogenic signals through phosphorylation of its cytosolic domain. To study innate cellular mechanisms for containing Her2 oncogenic phosphorylation, a siRNA phosphatase library was screened for cellular phosphatase(s) that enhance phosphorylation in the signaling motif of Her2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.