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Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants

16 Jul 2022

Abstract excerpt

The B.1.1.529 (omicron) variant has rapidly supplanted most other SARS-CoV-2 variants. Using microfluidics-based antibody affinity profiling (MAAP), we have characterized affinity and IgG concentration in the plasma of 39 individuals with multiple trajectories of SARS-CoV-2 infection and/or vaccination. Antibody affinity was similar against the wild-type, delta, and omicron variants ( K A ranges: 122 ± 155, 159 ±...

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PMID: 35875683
DOI: 10.1016/j.isci.2022.104766

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