Article

Installation of Dominant-Negative Mutations in <i>FAS</i> and <i>TGFβR2</i> via Base Editing in Primary T Cells

2025-09-16

Abstract excerpt

Adoptive cell transfer (ACT) of engineered T cells is effective against B-cell malignancies but has faltered against solid tumors due to the immunosuppressive tumor microenvironment (TME). FASL and TGFβ are key mediators of T cell dysfunction in the TME and overexpressing dominant negative (dn) forms of their receptors in T cells increases anti-tumor efficacy in solid tumor models. However, an approach which direc...

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Literature Corpus work: b13ff3d5-1707-5fde-ace3-fb1475149bb0
DOI: 10.1101/2025.09.11.675648

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