Article

Comprehensive genome editing confers ‘off-the-shelf’ CAR-T cells superior efficacy against solid tumors

2023-08-04

Abstract excerpt

Biochemical and immunological negative regulators converge to inhibit tumor-reactive Chimeric Antigen Receptor T (CAR-T) cells, which may explain clinical failures of CAR-T cell therapies against solid tumors. Here, we developed a multifaceted approach to genetically engineer allogeneic (‘off -the-shelf’) CAR-T cells resistant to both biochemical (adenosine) and immunological (PD-L1 and TGF-β) inhibitory signaling...

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Literature Corpus work: 87d373e4-fc3a-57e0-a989-b62fa068aeea
DOI: 10.1101/2023.08.03.551705

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