Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9.

The EMBO journal - 15 Dec 2020

Winklemann Iven, Matsuoka Rei, Meier Pascal F, Shutin Denis, Zhang Chenou, Orellana Laura, Sexton Ricky, Landreh Michael, Robinson Carol V, Beckstein Oliver, Drew David

Abstract excerpt

Na+ /H+ exchangers (NHEs) are ancient membrane-bound nanomachines that work to regulate intracellular pH, sodium levels and cell volume. NHE activities contribute to the control of the cell cycle, cell proliferation, cell migration and vesicle trafficking. NHE dysfunction has been linked to many diseases, and they are targets of pharmaceutical drugs. Despite their fundamental importance to cell homeostasis and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cryoelectron Microscopy
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Horses

Share to Molecular Dynamics Simulation

Share to Protein Isoforms

Share to Protons

Share to Sodium

Share to Sodium-Hydrogen Exchangers

Source

Open in PubMed Open full text

Identifiers

PMID: 33118634
DOI: 10.15252/embj.2020105908
PMCID: PMC7737618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9.PMID 33118634Read ↗

Integrative structural analysis of the human endosomal Na⁺/H⁺ exchanger NHE6 reveals a lipid-stabilized intracellular gate and a disordered C-terminusSemantic proximity Read ↗

Functional evaluation of autism-associated mutations in NHE9.Semantic proximity Read ↗

Sodium hydrogen exchanger 9 NHE9 (SLC9A9) and its emerging roles in neuropsychiatric comorbidity.Semantic proximity Read ↗

Structural basis of augment taurine uptake by taurine transporter alleviating cellular senescenceSemantic proximity Read ↗

Diversity of the mammalian sodium/proton exchanger SLC9 gene family.Semantic proximity Read ↗

Structural basis for amino acid exchange by a human heteromeric amino acid transporterSemantic proximity Read ↗

Cloning, Characterization, and Chromosomal Mapping of a Human Electroneutral Na+-driven Cl-HCO3ExchangerSemantic proximity Read ↗

A mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogens.Semantic proximity Read ↗

Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion ExchangerSemantic proximity Read ↗

The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 trafficking.Semantic proximity Read ↗

To be or not to be an ion channel: cryo-EM structures have a saySemantic proximity Read ↗

Molecular Simulations Meet Personalized Medicine. The Mechanism of Action of ClC-5 Antiporter and the Origin of Dent’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.