Article
X-ray diffraction studies on merohedrally twinned Δ1-62NtNBCe1-A crystals of the sodium/bicarbonate cotransporter.
Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Jul 2013
Gill Harindarpal S, Dutcher Lauren, Boron Walter F, Patel Samir, Guay-Woodford Lisa M
Abstract excerpt
NBCe1-A membrane-embedded macromolecules that cotransport sodium and bicarbonate ions across the bilayer serve to maintain acid-base homeostasis throughout the body. Defects result in a number of renal and eye disorders, including type-II renal tubular acidosis and cataracts. Here, crystals of a human truncated mutant of the cytoplasmic N-terminal domain of NBCe1 (Δ1-62NtNBCe1-A) are reported that diffract X-rays...
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