Article

Mitochondrial H <sub>2</sub> O <sub>2</sub> release does not directly cause genomic DNA damage

2023-03-30

Abstract excerpt

Reactive Oxygen Species (ROS) derived from mitochondrial respiration are frequently cited as a major source of genomic DNA damage and subsequent mutations that contribute to cancer development and aging. However, experimental evidence showing that ROS released by mitochondrial can directly damage nuclear DNA under (patho)physiological conditions has been largely lacking. In this study we modeled the effects of mit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b10ad660-537f-5e7b-b209-634e32336532
DOI: 10.1101/2023.03.29.534749

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial H <sub>2</sub> O <sub>2</sub> release does not directly cause genomic DNA damageDOI 10.1101/2023.03.29.534749Read

Direct quantification of chemogenetic H <sub>2</sub> O <sub>2</sub> production in live human cellsSemantic proximity Read

Hydrogen Peroxide induces resistance to DNA damage in a localization and p53 dependent mannerSemantic proximity Read

Cell-free chromatin particles damage genomic DNA of healthy cells via an ROS-independent mechanismSemantic proximity Read

Cell-free chromatin particles damage genomic DNA of healthy cells via an ROS-independent mechanismSemantic proximity Read

Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cellsSemantic proximity Read

Oxidative Stress Induces Persistent Telomeric DNA Damage Responsible for Nuclear Morphology Change in Mammalian CellsSemantic proximity Read

Heme-Containing Enzymes Generate Hydrogen Peroxide from Molecular Hydrogen: Implications for Redox Signaling in Human CellsSemantic proximity Read

Microenvironment-Cell Nucleus Relationship in the Context of Oxidative StressSemantic proximity Read

Telomeric 8-Oxoguanine Drives Rapid Premature Senescence In The Absence Of Telomere ShorteningSemantic proximity Read

Measurements of Hydrogen Peroxide and Oxidative DNA Damage in a Cell Model of Premature Aging.Semantic proximity Read

Human Myometrial Cell Fate under Chronic Oxidative Stress for LeiomyomagenesisSemantic proximity Read

Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts.Semantic proximity Read