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Article

Microenvironment-Cell Nucleus Relationship in the Context of Oxidative Stress

9 Mar 2018

Abstract excerpt

The microenvironment is a source of reactive oxygen species (ROS) that influence cell phenotype and tissue homeostasis. The impact of ROS on redox pathways as well as directly on epigenetic mechanisms and the DNA illustrate communication with the cell nucleus. Changes in gene transcription related to redox conditions also influence the content and structure of the extracellular matrix. However, the importance of...

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PMID: 29594114
DOI: 10.3389/fcell.2018.00023

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