Article

Cell-free chromatin particles damage genomic DNA of healthy cells via an ROS-independent mechanism

2024-09-02

Abstract excerpt

<title>Abstract</title> <p>Several hundred billion cells die daily in the human body, releasing cell-free chromatin particles (cfChPs) in the process, which then enter the blood circulationand get taken up by healthy cells. We have previously reported that, these internalized cfChPs damage genomic DNA as well cause physical damage to mitochondria, resulting in increased mitochondrial ROS production. In the curren...

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Literature Corpus work: ad83e3aa-1b87-505c-ad0c-8e0be8726099
DOI: 10.21203/rs.3.rs-4873371/v1

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