Conformational and Functional Regulation of SET by Legumain Cleavage

Abstract excerpt

The cysteine protease legumain typically localizes to the endolysosomal system, where it is an important player in the immune system. However, in the context of Alzheimer’s disease (AD), legumain has been shown to be translocated to the cytosol, where it cleaves SET, synonymously termed TAF-1 or I2PP2A, an inhibitor of protein phosphatase 2A. SET is primarily found in the nucleus, where it regulates gene transcrip...

Topics

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• Complement Factor H
• Genetic Predisposition to Disease
• Models, Molecular
• Peptidase Inhibition and Analysis
• Peptides
• Protease and Inhibitor Mechanisms
• Protein Domains
• Substrate Specificity

Identifiers and source

Literature Corpus work

b0e9f49c-5f83-5d42-af1b-2c35d61b043d

DOI

10.1101/2025.01.28.635311