Article

Legumain (asparaginyl endopeptidase) modulates extracellular matrix dynamics in pulmonary fibrosis

2026-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Pulmonary fibrosis is characterized by extracellular matrix (ECM) deposition driven by fibroblast-to-myofibroblast transition (FMT) and by an altered proteolytic balance. While the roles of several cysteine proteases have been documented, the specific contribution of cathepsin V (CatV) and legumain (LGMN) remains poorly explored. LGMN, CatV and their dual inhibitor cystatin M/E (CysM/E) are sign...

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Literature Corpus work: 0387af24-a650-544f-90fb-617e80253b86
DOI: 10.64898/2026.07.20.739492

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