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Article

Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins.

Biochemical Society transactions - 15 Aug 2017

Saint-Pol Julien, Eschenbrenner Etienne, Dornier Emmanuel, Boucheix Claude, Charrin Stéphanie, Rubinstein Eric

Abstract excerpt

By interacting directly with partner proteins and with one another, tetraspanins organize a network of interactions referred to as the tetraspanin web. ADAM10 (A Disintegrin And Metalloprotease 10), an essential membrane-anchored metalloprotease that cleaves off the ectodomain of a large variety of cell surface proteins including cytokines, adhesion molecules, the precursor of the β-amyloid peptide APP or Notch,...

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Source

Identifiers

PMID: 28687716
DOI: 10.1042/BST20160296

Genes

ADAM10
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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