Article
Tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex
2019-10-11
Abstract excerpt
A disintegrin and metalloprotease 10 (ADAM10) is essential for embryonic development and impacts on diseases such as cancer, Alzheimer’s and inflammatory diseases. ADAM10 is a ‘molecular scissor’ that proteolytically cleaves the extracellular region from over 100 substrates, including Notch, amyloid precursor protein, cadherins, growth factors and chemokines. ADAM10 was recently proposed to function as six distinc...
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Identifiers and source
- Literature Corpus work
- fb67e3f9-fb11-5208-b696-c28e696beb1a
- DOI
- 10.1101/800557