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Article

Her2 amplification, Rel-A, and Bach1 can influence APOBEC3A expression in breast cancer cells.

PLoS genetics - 1 May 2024

Dennis Madeline, Hurley Alyssa, Bray Nicholas, Cordero Cameron, Ilagan Jose, Mertz Tony M, Roberts Steven A

Abstract excerpt

APOBEC-induced mutations occur in 50% of sequenced human tumors, with APOBEC3A (A3A) being a major contributor to mutagenesis in breast cancer cells. The mechanisms that cause A3A activation and mutagenesis in breast cancers are still unknown. Here, we describe factors that influence basal A3A mRNA transcript levels in breast cancer cells. We found that basal A3A mRNA correlates with A3A protein levels and...

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Share to Basic-Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

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Source

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Identifiers

PMID: 38805570
DOI: 10.1371/journal.pgen.1011293
PMCID: PMC11161071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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