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Variational autoencoders to predict DNA-methylation age and provide biological insights in age-related health and disease

2023-07-08

Abstract excerpt

<h4>Motivation</h4> Epigenetic ageing clocks based on age-associated changes in DNA-methylation (DNAm) profiles have shown great potential as predictors to quantify age-related health and disease. Most of these clocks are built using penalized linear regression models with the aim to predict chronological and/or biological age. However, the precise underlying biological mechanisms influencing these clocks remain u...

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Literature Corpus work
b0c85059-e1c9-536e-ac42-163466f0266b
DOI
10.1101/2023.07.07.23292381
Open publication

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Variational autoencoders to predict DNA-methylation age and provide biological insights in age-related health and diseaseDOI 10.1101/2023.07.07.23292381
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