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Repurposing host-guest chemistry to sequester virulence and eradicate biofilms in multidrug resistant <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i>

2023-03-01

Abstract excerpt

The limited diversity in targets of available antibiotic therapies has put tremendous pressure on the treatment of bacterial pathogens, where numerous resistance mechanisms that counteract their function are becoming increasingly prevalent. Here, we utilize an unconventional anti-virulence screen of host-guest interacting macrocycles, and identify a water-soluble synthetic macrocycle, Pillar[5]arene, that is non-b...

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Literature Corpus work
70bc0430-009d-5a26-ab43-a70625bf636b
DOI
10.1101/2023.03.01.530582
Open publication

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Repurposing host-guest chemistry to sequester virulence and eradicate biofilms in multidrug resistant <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i>DOI 10.1101/2023.03.01.530582
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