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Orally available designed miniproteins inhibit enterotoxigenic <i>Bacteroides fragilis</i> pathology by blocking toxin receptor binding

2026-06-23

Abstract excerpt

Toxigenic bacterial infections in the gut are a significant contributor to the global burden of disease. Advanced tools for protein and live biotherapeutic engineering offer potentially transformative strategies for treating such diseases, while avoiding the collateral effects of traditional antibacterials. Here we used de novo protein design to identify inhibitors of the metzincin family protease Bacteroides fra...

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Literature Corpus work
c3ec5282-6a39-5aa8-b46c-20487baf8ebd
DOI
10.64898/2026.06.22.733822
Open publication

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Orally available designed miniproteins inhibit enterotoxigenic <i>Bacteroides fragilis</i> pathology by blocking toxin receptor bindingDOI 10.64898/2026.06.22.733822
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