Article

Improving the immunogenicity of <i>E. coli</i> FimH via multivalent display on I53-50 nanoparticles

2026-03-09

Abstract excerpt

Urinary tract infections, caused primarily by uropathogenic E. coli , are a significant public health burden, affecting approximately 50% of women worldwide. The adhesin FimH is responsible for host receptor binding and is therefore a promising vaccine candidate, but prior studies showed that recombinant monomeric FimH is poorly immunogenic. Here we displayed FimH antigens on the two-component protein nanoparticl...

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Literature Corpus work: 68d88e39-6764-5310-b2df-1cd45da7bfc3
DOI: 10.64898/2026.03.05.709951

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