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Article

Single-cell analysis reveals the implication of vascular endothelial cell-intrinsic ANGPT2 in human intracranial aneurysm.

Cardiovascular research - 6 May 2025

Yu Guo, Li Jia, Zhang Hongfei, Zi Huaxing, Liu Mingjian, An Qingzhu, Qiu Tianming, Li Peiliang, Song Jianping, Liu Peixi, Quan Kai, Li Sichen, Liu Yingjun, Zhu Wei, Du Jiulin

Abstract excerpt

AIMS: While previous single-cell RNA sequencing (scRNA-seq) studies have attempted to dissect intracranial aneurysm (IA), the primary molecular mechanism for IA pathogenesis remains unknown. Here, we uncovered the alterations of cellular compositions, especially the transcriptome changes of vascular endothelial cells (ECs), in human IA. METHODS AND RESULTS: We performed scRNA-seq to compare the cell atlas of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39187926
DOI: 10.1093/cvr/cvae186

Genes

ANGPT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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