Article
Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for Intracranial Aneurysms.
Circulation. Genomic and precision medicine - 1 Jul 2018
Yang Xinyu, Li Jiani, Fang Yabo, Zhang Zhen, Jin Daqing, Chen Xingdong, Zhao Yan, Li Mengqi, Huan Linchun, Kent Thomas A, Dong Jing-Fei, Jiang Rongcai, Yang Shuyuan, Jin Li, Zhang Jianning, Zhong Tao P, Yu Fuli
Abstract excerpt
BACKGROUND: Intracranial aneurysm (IA) is usually a late-onset disease, affecting 1% to 3% of the general population and leading to life-threatening subarachnoid hemorrhage. Genetic susceptibility has been implicated in IAs, but the causative genes remain elusive. METHODS: We performed next-generation sequencing in a discovery cohort of 20 Chinese IA patients. Bioinformatics filters were exploited to search for...
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