Article
Genome-wide association study of intracranial aneurysm identifies three new risk loci.
Nature genetics - 1 May 2010
Yasuno Katsuhito, Bilguvar Kaya, Bijlenga Philippe, Low Siew-Kee, Krischek Boris, Auburger Georg, Simon Matthias, Krex Dietmar, Arlier Zulfikar, Nayak Nikhil, Ruigrok Ynte M, Niemelä Mika, Tajima Atsushi, von und zu Fraunberg Mikael, Dóczi Tamás, Wirjatijasa Florentina, Hata Akira, Blasco Jordi, Oszvald Agi, Kasuya Hidetoshi, Zilani Gulam, Schoch Beate, Singh Pankaj, Stüer Carsten, Risselada Roelof, Beck Jürgen, Sola Teresa, Ricciardi Filomena, Aromaa Arpo, Illig Thomas, Schreiber Stefan, van Duijn Cornelia M, van den Berg Leonard H, Perret Claire, Proust Carole, Roder Constantin, Ozturk Ali K, Gaál Emília, Berg Daniela, Geisen Christof, Friedrich Christoph M, Summers Paul, Frangi Alejandro F, State Matthew W, Wichmann H Erich, Breteler Monique M B, Wijmenga Cisca, Mane Shrikant, Peltonen Leena, Elio Vivas, Sturkenboom Miriam C J M, Lawford Patricia, Byrne James, Macho Juan, Sandalcioglu Erol I, Meyer Bernhard, Raabe Andreas, Steinmetz Helmuth, Rüfenacht Daniel, Jääskeläinen Juha E, Hernesniemi Juha, Rinkel Gabriel J E, Zembutsu Hitoshi, Inoue Ituro, Palotie Aarno, Cambien François, Nakamura Yusuke, Lifton Richard P, Günel Murat
Abstract excerpt
Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall; their hemorrhage commonly results in severe neurologic impairment and death. We report a second genome-wide association study with discovery and replication cohorts from Europe and Japan comprising 5,891 cases and 14,181 controls with approximately 832,000 genotyped and imputed SNPs across discovery cohorts. We...
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