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Article

Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics.

Scientific reports - 6 Jul 2023

Rodrigues Lucas, Watson Joshua, Feng Yuan, Lewis Benjamin, Harvey Garrett, Post Gerald, Megquier Kate, White Michelle E, Lambert Lindsay, Miller Aubrey, Lopes Christina, Zhao Shaying

Abstract excerpt

Naturally occurring canine cancers have remarkable similarities to their human counterparts. To better understand these similarities, we investigated 671 client-owned dogs from 96 breeds with 23 common tumor types, including those whose mutation profile are unknown (anal sac carcinoma and neuroendocrine carcinoma) or understudied (thyroid carcinoma, soft tissue sarcoma and hepatocellular carcinoma). We discovered...

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Source

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Identifiers

PMID: 37414794
DOI: 10.1038/s41598-023-37505-2
PMCID: PMC10325973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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