Article

Shared hotspot mutations in spontaneously arising cancers position dog as an unparalleled comparative model for precision therapeutics

2021-10-24

Abstract excerpt

Naturally occurring canine cancers have remarkable similarities to their human counterparts. In order to determine whether these similarities occur at the molecular level, we investigated hotspot mutations in a variety of spontaneously arising canine cancers and found high concordance in oncogenic drivers between cancers in both species. These findings suggest that canines may present a powerful and complementary...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6364fe97-9d40-5ce2-9ae0-ca792f455c7b
DOI: 10.1101/2021.10.22.465469

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Shared hotspot mutations in spontaneously arising cancers position dog as an unparalleled comparative model for precision therapeuticsDOI 10.1101/2021.10.22.465469Read

Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics.Semantic proximity Read

Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogsSemantic proximity Read

Canine tumor mutation rate is positively correlated with TP53 mutation across cancer types and breedsSemantic proximity Read

Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds.Semantic proximity Read

Identification of frequent activating <i>HER2</i> mutations in primary canine pulmonary adenocarcinomaSemantic proximity Read

Bringing the Genomic Revolution to Comparative Oncology: Human and Dog CancersSemantic proximity Read

PIK3CA is recurrently mutated in canine mammary tumors, similarly to in human mammary neoplasiaSemantic proximity Read

Molecular Parallelisms and Divergences Between Human and Canine Cancers Would a dog be an appropriate experimental model for human cancers?Semantic proximity Read

The Genetic Landscape of Canine Tumors: Insights from the Canine Cancer Genome Atlas (CCGA)Semantic proximity Read

Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome SequencingSemantic proximity Read

Exploring the Therapeutic Potential of BRCA1 and BRCA2 as Targets in Canine Oncology: A Comprehensive Review of Their Role in Cancer Development and TreatmentSemantic proximity Read