Article
Unraveling the chaotic genomic landscape of primary and metastatic canine appendicular osteosarcoma with current sequencing technologies and bioinformatic approaches.
PloS one - 1 Jan 2021
Chu Shirley, Skidmore Zachary L, Kunisaki Jason, Walker Jason R, Griffith Malachi, Griffith Obi L, Bryan Jeffrey N
Abstract excerpt
Osteosarcoma is a rare disease in children but is one of the most common cancers in adult large breed dogs. The mutational landscape of both the primary and pulmonary metastatic tumor in two dogs with appendicular osteosarcoma (OSA) was comprehensively evaluated using an automated whole genome sequencing, exome and RNA-seq pipeline that was adapted for this study for use in dogs. Chromosomal lesions were the most...
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