Article

Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

2022-12-10

Abstract excerpt

<h4>Background</h4> The overactivation of NF-κB signaling is a key hallmark for the pathogenesis of extranodal natural killer/T cell lymphoma (ENKTL), a very aggressive subtype of non-Hodgkin’s lymphoma yet with rather limited control strategies. Previously, we found that the dysregulated exportin-1 (also known as CRM1) is mainly responsible for tumor cells to evade apoptosis and promote tumor-associated pathways...

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Literature Corpus work: b06e07d7-7704-5c10-9315-9ffd25cde95c
DOI: 10.1101/2022.12.06.519362

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