Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

31 Jul 2012

Abstract excerpt

Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as therapeutics for leukemia, but existing CRM1 inhibitors show variable potencies and a broad range of cytotoxic effects. Here, we report the structural analysis and antileukemic activity of a new generation of small-molecule inhibitors of CRM1. Designated selective inhibitors of nuclear export...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Nuclear Structure and Function
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22847027
DOI: 10.1038/leu.2012.219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cellsPMID 22847027Read ↗

Inhibiting cancer cell hallmark features through nuclear export inhibitionSemantic proximity Read ↗

Small Molecule Inhibitors of CRM1Semantic proximity Read ↗

<scp>KPT</scp>‐330 inhibitor of <scp>CRM</scp>1 (<scp>XPO</scp>1)‐mediated nuclear export has selective anti‐leukaemic activity in preclinical models of <scp>T</scp>‐cell acute lymphoblastic leukaemia and acute myeloid leukaemiaSemantic proximity Read ↗

Chromosome Region Maintenance 1 (XPO1/CRM1) as an Anticancer Target and Discovery of Its InhibitorSemantic proximity Read ↗

SINE (selective inhibitor of nuclear export) – translational science in a new class of anti-cancer agentsSemantic proximity Read ↗

The past, present, and future of CRM1/XPO1 inhibitorsSemantic proximity Read ↗

Selective inhibitors of nuclear export (SINE)– a novel class of anti-cancer agentsSemantic proximity Read ↗

Revumenib for patients with acute leukemia: a new tool for differentiation therapySemantic proximity Read ↗

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Prognostic impact and targeting of CRM1 in acute myeloid leukemiaSemantic proximity Read ↗

Characterization of Inhibition Reveals Distinctive Properties for Human and Saccharomyces cerevisiae CRM1.Semantic proximity Read ↗

Targeting nuclear import and export in hematological malignanciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.