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Article

PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis

1 Jan 2015

Abstract excerpt

Mitotic kinases are the key components of the cell cycle machinery and play vital roles in cell cycle progression. PLK-1 (Polo-like kinase-1) is a crucial mitotic protein kinase that plays an essential role in both the onset of G2/M transition and cytokinesis. The overexpression of PLK-1 is strongly correlated with a wide spectrum of human cancers and poor prognosis. The (si)RNA-mediated depletion of PLK-1...

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Identifiers

PMID: 26557691
DOI: 10.1155/2015/705745

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