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Article

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

10 Jun 2014

Abstract excerpt

Cereblon (CRBN) mediates immunomodulatory drug (IMiD) action in multiple myeloma (MM). Using 2 different methodologies, we identified 244 CRBN binding proteins and established relevance to MM biology by changes in their abundance after exposure to lenalidomide. Proteins most reproducibly binding CRBN (>fourfold vs controls) included DDB1, CUL4A, IKZF1, KPNA2, LTF, PFKL, PRKAR2A, RANGAP1, and SHMT2. After...

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PMID: 24914135
DOI: 10.1182/blood-2014-02-557819

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