Article
Epigenetic dysregulation of eukaryotic initiation factor 3 subunit E (eIF3E) by lysine methyltransferase REIIBP confers a pro-inflammatory phenotype in t(4;14) myeloma.
Haematologica - 1 Jun 2024
Chong Phyllis S Y, Chooi Jing Yuan, Lim Sze Lynn Julia, Chung Tae-Hoon, Brunmeir Reinhard, Leow Aaron Chung Yong, Toh Sabrina Hui Min, Balan Kalpnaa, Azaman Muhamad Irfan Bin, Wu Zhengwei, Subramaniam Nagavidya, Vardy Leah A, Chng Wee-Joo
Abstract excerpt
REIIBP is a lysine methyltransferase aberrantly expressed through alternative promoter usage of NSD2 locus in t(4;14)-translocated multiple myeloma (MM). Clinically, t(4;14) translocation is an adverse prognostic factor found in approximately 15% of MM patients. The contribution of REIIBP relative to other NSD2 isoforms as a dependency gene in t(4;14)-translocated MM remains to be evaluated. Here, we demonstrated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.