Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.

Abstract excerpt

Many craniofacial disorders are caused by heterozygous mutations in general regulators of housekeeping cellular functions such as transcription or ribosome biogenesis. Although it is understood that many of these malformations are a consequence of defects in cranial neural crest cells, a cell type that gives rise to most of the facial structures during embryogenesis, the mechanism underlying cell-type selectivity...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Benzothiazoles
• Share to Cell Nucleolus