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Article

RNA Polymerase III subunit Polr3a is required for craniofacial cartilage and bone development in zebrafish.

PLoS genetics - 1 Jun 2026

Lubash Bailey T, Gutierrez Roxana, Hansen Nicole A, Fink Kade, Hopkins Colette A, Sands Lauren B, Nelson Jessica C, Watt Kristin E N

Abstract excerpt

Transcription by RNA Polymerase III (Pol III) is essential for ribosome biogenesis and translation in all cells, but pathogenic variants in genes encoding subunits of Pol III lead to tissue-specific phenotypes including craniofacial differences. To understand the function of Pol III in craniofacial development, we examined polr3a mutant zebrafish. These mutants display hypoplasia of the neural crest cell-derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42258504
DOI: 10.1371/journal.pgen.1012164
PMCID: PMC13262943

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