Article

RNA Polymerase III subunit Polr3a is required for craniofacial cartilage and bone development in zebrafish

2026-01-09

Abstract excerpt

Transcription by RNA Polymerase III (Pol III) is essential for ribosome biogenesis and translation in all cells, but pathogenic variants in genes encoding subunits of Pol III lead to tissue-specific phenotypes including craniofacial differences. To understand the function of Pol III in craniofacial development, we examined polr3a mutant zebrafish. These mutants display hypoplasia of the neural crest cell-derived...

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Literature Corpus work: 6deca286-5ad6-5c06-9771-3011de37990a
DOI: 10.64898/2026.01.09.698267

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