Article

Ubr1-induced selective endo-phagy/autophagy protects against the endosomal and Ca <sup>2+</sup> -induced proteostasis disease stress

2021-10-05

Abstract excerpt

The defence mechanisms against endo-lysosomal homeostasis stress remain incompletely understood. Here, we identify Ubr1 as a protein quality control (QC) ubiquitin ligase that counteracts proteostasis stress by enhancing cargo selective autophagy for lysosomal degradation. Astrocyte regulatory cluster membrane protein MLC1 mutations increased intracellular Ca 2+ and caused endosomal compartment stress by fusion a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b0503360-cdd8-52d3-9100-20dc770a75cc
DOI: 10.1101/2021.10.05.463117

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ubr1-induced selective endo-phagy/autophagy protects against the endosomal and Ca <sup>2+</sup> -induced proteostasis disease stressDOI 10.1101/2021.10.05.463117Read

Lysosomal quality control ReviewSemantic proximity Read

Differential regulation of p62-ubiquitin conjugates in neurons versus astrocytes during cellular stressSemantic proximity Read

Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticitySemantic proximity Read

Combinatorial selective ER-phagy remodels the ER during neurogenesisSemantic proximity Read

Sorting Nexins in Protein HomeostasisSemantic proximity Read

Lysosomal Calcium Channels in Autophagy and CancerSemantic proximity Read

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.Semantic proximity Read

The Lysosome as a Regulatory HubSemantic proximity Read

Sorting Nexins in Protein HomeostasisSemantic proximity Read

The Endolysosomal System and Proteostasis: From Development to DegenerationSemantic proximity Read

Mitochondrial Ca2+ homeostasis in lysosomal storage diseases.Semantic proximity Read

Lysosome and endoplasmic reticulum quality control pathways in Niemann-Pick type C disease.Semantic proximity Read