Article
Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2015
Wang Wuyang, Gao Qiong, Yang Meimei, Zhang Xiaoli, Yu Lu, Lawas Maria, Li Xinran, Bryant-Genevier Marthe, Southall Noel T, Marugan Juan, Ferrer Marc, Xu Haoxing
Abstract excerpt
Upon nutrient starvation, autophagy digests unwanted cellular components to generate catabolites that are required for housekeeping biosynthesis processes. A complete execution of autophagy demands an enhancement in lysosome function and biogenesis to match the increase in autophagosome formation. Here, we report that mucolipin-1 (also known as TRPML1 or ML1), a Ca(2+) channel in the lysosome that regulates many...
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