Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders.

doi:10.1038/nn.3484

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Article

Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders.

Nature neuroscience - 1 Sept 2013

Stoll Georg, Pietiläinen Olli P H, Linder Bastian, Suvisaari Jaana, Brosi Cornelia, Hennah William, Leppä Virpi, Torniainen Minna, Ripatti Samuli, Ala-Mello Sirpa, Plöttner Oliver, Rehnström Karola, Tuulio-Henriksson Annamari, Varilo Teppo, Tallila Jonna, Kristiansson Kati, Isohanni Matti, Kaprio Jaakko, Eriksson Johan G, Raitakari Olli T, Lehtimäki Terho, Jarvelin Marjo-Riitta, Salomaa Veikko, Hurles Matthew, Stefansson Hreinn, Peltonen Leena, Sullivan Patrick F, Paunio Tiina, Lönnqvist Jouko, Daly Mark J, Fischer Utz, Freimer Nelson B, Palotie Aarno

Abstract excerpt

Implicating particular genes in the generation of complex brain and behavior phenotypes requires multiple lines of evidence. The rarity of most high-impact genetic variants typically precludes the possibility of accruing statistical evidence that they are associated with a given trait. We found t...

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PMID: 23912948
DOI: 10.1038/nn.3484
PMCID: PMC3986889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23912948-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

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