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Article

The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity.

Molecular biology reports - 1 Mar 2014

Rovite Vita, Petrovska Ramona, Vaivade Iveta, Kalnina Ineta, Fridmanis Davids, Zaharenko Linda, Peculis Raitis, Pirags Valdis, Schioth Helgi B, Klovins Janis

Abstract excerpt

Melanocortin 4 receptor (MC4R) is an important regulator of food intake and number of studies report genetic variations influencing the risk of obesity. Here we explored the role of common genetic variation from MC4R locus comparing with SNPs from gene FTO locus, as well as the frequency and functionality of rare MC4R mutations in cohort of 380 severely obese individuals (BMI > 39 kg/m(2)) and 380 lean subjects...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24385306
DOI: 10.1007/s11033-013-2994-4

Genes

FTO
AGRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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