Article

Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core

2022-01-16

Abstract excerpt

Children with Down syndrome (DS) are predisposed to developing megakaryoblastic leukemia (ML-DS) and often experience severe toxicities from chemotherapy, highlighting the need for targeted therapies with beneficial risk profiles. The genomic landscape of ML-DS is characterized by a combination of mutations in signaling pathway genes and epigenetic modifiers, while aberrant lysine specific demethylase 1 (LSD1) and...

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Literature Corpus work: 8fdadb00-64c0-5fca-83f9-f439d26f0dad
DOI: 10.1101/2022.01.14.476342

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