Article

LSD1 Performs Demethylase-Independent and Context-Specific Roles in Ewing Sarcoma

2025-12-09

Abstract excerpt

<h4>ABSTRACT</h4> L ysine s pecific d emethylase 1 (LSD1), encoded by the gene KDM1A , is overexpressed and correlates with poor patient prognosis in Ewing sarcoma. LSD1 and the pathognomonic fusion oncoprotein, EWSR1::FLI1, colocalize throughout the genome, suggesting LSD1 is a critical co-regulator driving the progression of Ewing sarcoma. However, therapeutic targeting of LSD1 by competitive and noncompetit...

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Literature Corpus work: 0e74ab70-0970-5763-8bc7-0733be419f05
DOI: 10.64898/2025.12.04.692414

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