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Insulin signaling regulates <i>Pink1</i> mRNA localization via modulation of AMPK activity to support PINK1 function in neurons

2023-02-06

Abstract excerpt

Mitochondrial quality control failure is frequently observed in neurodegenerative diseases. The detection of damaged mitochondria by stabilization of PTEN-induced kinase 1 (PINK1) requires transport of Pink1 mRNA by tethering it to the mitochondrial surface. Here, we report that inhibition of AMPK by activation of the insulin signaling cascade prevents Pink1 mRNA binding to mitochondria. Mechanistically, AMPK ph...

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Identifiers and source

Literature Corpus work
b02d043c-8e71-50b4-98b2-bc5d175f7989
DOI
10.1101/2023.02.06.527276
Open publication

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Insulin signaling regulates <i>Pink1</i> mRNA localization via modulation of AMPK activity to support PINK1 function in neuronsDOI 10.1101/2023.02.06.527276
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