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Article

PP2Cα aggravates neuronal insulin resistance leading to AD-like phenotype in vitro.

Biochemical and biophysical research communications - 12 Feb 2023

Yadav Yamini, Dey Chinmoy Sankar

Abstract excerpt

Neuronal insulin resistance is a major risk for development of Alzheimer's Disease (AD). Studies already reported few kinases participating in neuronal insulin signaling connected with progression of AD pathogenesis, yet complete information is missing. α isoform of Protein Phosphatase-2C (PP2C) is a Ser/Thr phosphatase, only known in 3T3-L1 adipocytes as a positive regulator of insulin signaling. However, many...

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Identifiers

PMID: 36630734
DOI: 10.1016/j.bbrc.2023.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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