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Article

Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge

17 May 2023

Abstract excerpt

Understanding immune mechanisms that mediate malaria protection is critical for improving vaccine development. Vaccination with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) induces high level of sterilizing immunity against malaria and serves as a valuable tool for the study of protective mechanisms. To identify vaccine-induced and protection-associated responses during malarial infection, we...

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PMID: 37195999
DOI: 10.1371/journal.ppat.1011051

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