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Systems analysis of immune responses to attenuated <i>P. falciparum</i> malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity

2021-07-29

Abstract excerpt

Immunization with radiation-attenuated sporozoites (RAS) can confer sterilizing protection against malaria, although the mechanisms behind this protection are incompletely understood. We performed a systems biology analysis of samples from the Immunization by M osquito with R adiation A ttenuated S porozoites IMRAS) trial, which comprised P. falciparum RAS-immunized ( Pf RAS), malaria-naive participants whos...

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Literature Corpus work
b78f530c-6c95-5326-b6b6-2c923a743c98
DOI
10.1101/2021.07.28.454252
Open publication

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Systems analysis of immune responses to attenuated <i>P. falciparum</i> malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunityDOI 10.1101/2021.07.28.454252
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