Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses

16 Apr 2016

Abstract excerpt

Despite decades of research, malaria remains a global health crisis. Current subunit vaccine approaches do not provide efficient long-term, sterilizing immunity against Plasmodium infections in humans. Conversely, whole parasite vaccinations with their larger array of target Ags have conferred long-lasting sterilizing protection to humans. Similar studies in rodent models of malaria reveal that CD8(+) T cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27084099
DOI: 10.4049/jimmunol.1600155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell ResponsesPMID 27084099Read ↗

Importance of the Immunodominant CD8 + T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced ProtectionSemantic proximity Read ↗

Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccinationSemantic proximity Read ↗

Correlative humoral and cellular immunity to genetically attenuated malaria parasites in humansSemantic proximity Read ↗

A T-cell response to a liver-stage <i>Plasmodium</i> antigen is not boosted by repeated sporozoite immunizationsSemantic proximity Read ↗

Dissecting the CD8+ T cell responses to pre-erythrocytic malaria antigensSemantic proximity Read ↗

Protective and pathogenic roles of CD8+ T cells during malaria infectionSemantic proximity Read ↗

Genetically Attenuated Plasmodium berghei Liver Stages Persist and Elicit Sterile Protection Primarily via CD8 T CellsSemantic proximity Read ↗

Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitroSemantic proximity Read ↗

Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccinationSemantic proximity Read ↗

A strong CD8+ T cell response is elicited using the synthetic polypeptide from the C-terminus of the circumsporozoite protein of Plasmodium berghei together with the adjuvant QS-21: quantitative and phenotypic comparison with the vaccine model of irradiated sporozoites.Semantic proximity Read ↗

Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive IndividualsSemantic proximity Read ↗

Class II-Restricted Protective Immunity Induced by Malaria SporozoitesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.