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Article

The influence of DNA and nucleosome structure on integration events directed by HIV integrase.

1 Oct 1994

Abstract excerpt

DNA copies of the human immunodeficiency virus (HIV) genome integrate nonrandomly into the chromosomal DNA of the host cell. In this report, we investigate the molecular basis of this selectivity using the virus-encoded HIV integrase to direct integration of a synthetic HIV long terminal repeat substrate into either DNA molecules of known structure or previously defined nucleosomal complexes. We find that the...

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PMID: 7929189
DOI: 10.1016/s0021-9258(17)31494-1

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