Article

Retrotransposons hijack alt-EJ DNA repair process for mobilization and eccDNA biogenesis

2022-09-26

Abstract excerpt

Parasitic retrotransposons populate in the genome to rewrite the hosts’ genetic code. How retrotransposons use the host factors to achieve their propagation remains largely unclear. Here we report retrotransposons hijack the alternative end-joining (alt-EJ) DNA repair process to accomplish mobilization cycle. We applied Nanopore sequencing to examine the fates of replicated retrotransposon DNA, and found that only...

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Literature Corpus work: 5248a2bd-e4a8-571b-a383-15a5861a9121
DOI: 10.1101/2022.09.25.509424

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