Article

Modulation of Human Immune Cells by Propyl Propane Thiosulfonate (PTSO) Inhibits Colorectal Tumor Progression in a Humanized Mouse Model

2025-09-01

Abstract excerpt

<h4>Background: </h4> /Objectives: Colorectal cancer (CRC) remains a major global health challenge and current therapies are not always effective. In addition, certain immune cell populations, such as myeloid-derived suppressor cells (MDSCs) pose a significant barrier to immune-based treatments. Some phytochemicals, particularly compounds derived from Allium spp. like Propyl Propane Thiosulfonate (PTSO), have show...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: afdf7a5b-00c4-55b0-a352-24b35bb959a7
DOI: 10.20944/preprints202508.2228.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modulation of Human Immune Cells by Propyl Propane Thiosulfonate (PTSO) Inhibits Colorectal Tumor Progression in a Humanized Mouse ModelDOI 10.20944/preprints202508.2228.v1Read

Targeting stemness pathways modulates macrophage polarization and reprograms the tumor microenvironmentSemantic proximity Read

Myeloid-Derived Suppressor Cells in Colorectal CancerSemantic proximity Read

MS275 induces tumor immunosuppression by up-regulating PD-L1 and enhances the efficacy of anti-PD-1 immunotherapy in colorectal cancerSemantic proximity Read

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathwaysSemantic proximity Read

Identification of thiostrepton as a novel therapeutic agent that targets human colon cancer stem cellsSemantic proximity Read

Tigecycline reduces tumorigenesis in colorectal cancer via inhibition of cell proliferation and modulation of immune response.Semantic proximity Read

Combination of the extract from Phellinus linteus with Smilax spp. attenuates colorectal and prostate cancersSemantic proximity Read

TGF-β type I receptor inhibitor suppresses polarization of tumor-associated macrophages to the M2 phenotype and exerts antitumor effects on colorectal cancerSemantic proximity Read

Bacillus mojavensis postbiotics: transcriptomic and anticancer effects in colon cancer cellsSemantic proximity Read

γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules.Semantic proximity Read

Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFβ1-targeting peptides P17 and P144.Semantic proximity Read

Combination of 5-fluorouracil and thymoquinone targets stem cell gene signature in colorectal cancer cellsSemantic proximity Read