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Targeting stemness pathways modulates macrophage polarization and reprograms the tumor microenvironment

14 Mar 2025

Abstract excerpt

Introduction The tumor microenvironment plays a pivotal role in cancer progression and therapeutic resistance, with tumor-associated macrophages significantly influencing immune suppression and tumor growth. Colorectal cancers (CRC) classified as Consensus Molecular Subtype 4 (CMS4) and triple-negative breast cancers subsets are particularly characterized by a mesenchymal phenotype, immune exclusion, and...

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PMID: 40160820
DOI: 10.3389/fimmu.2025.1513404

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