Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules.

British journal of cancer - 27 Sept 2016

Prasad Sahdeo, Gupta Subash C, Tyagi Amit K, Aggarwal Bharat B

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is one of the most common malignancies worldwide and even develops resistance to chemotherapeutic agents over time. As a result survival for patients with CRC remains poor. METHOD: We investigated both in vitro and in vivo effects of γ-tocotrienol (γ-T3) alone and in combination with capecitabine. Apoptosis and cytotoxicity assays were performed by MTT and FACS analysis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Capecitabine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromans

Share to Mice, Nude

Share to NF-kappa B

Share to Tumor Stem Cell Assay

Share to Vitamin E

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 27575851
DOI: 10.1038/bjc.2016.257
PMCID: PMC5046209

Genes

CXCR4
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules.PMID 27575851Read ↗

Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathwaysSemantic proximity Read ↗

Anticancer activities of tocotrienols: A Systematic Scoping ReviewSemantic proximity Read ↗

Natural products for treating colorectal cancer: A mechanistic reviewSemantic proximity Read ↗

Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phenotypes and Angiogenic Signaling in Colorectal Cancer Cells In Vitro.Semantic proximity Read ↗

Identification of Synergistic Interaction Between Cannabis-Derived Compounds for Cytotoxic Activity in Colorectal Cancer Cell Lines and Colon Polyps That Induces Apoptosis-Related Cell Death and Distinct Gene ExpressionSemantic proximity Read ↗

Evidence of<i>γ</i>-Tocotrienol as an Apoptosis-Inducing, Invasion-Suppressing, and Chemotherapy Drug-Sensitizing Agent in Human Melanoma CellsSemantic proximity Read ↗

Cincumol prevents malignant phenotype of colorectal cancer cell line HCT116 via inhibiting PI3K/AKT signaling in vitro.Semantic proximity Read ↗

Ginseng polysaccharide promotes the apoptosis of colon cancer cells via activating the NLRP3 inflammasomeSemantic proximity Read ↗

Polygonum Barbatum Extract Reduces Colorectal Cancer Cell Proliferation, Migration, Invasion, and Epithelial-mesenchymal Transition via Regulation of the YAP and β-catenin PathwaysSemantic proximity Read ↗

Resveratrol Chemosensitizes TNF-β-Induced Survival of 5-FU-Treated Colorectal Cancer Cells.Semantic proximity Read ↗

Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancerSemantic proximity Read ↗

The suppressing effects of BTG3 expression on aggressive behaviors and phenotypes of colorectal cancer: An in vitro and vivo study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.