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Article

Identification of thiostrepton as a novel therapeutic agent that targets human colon cancer stem cells

2 Jul 2015

Abstract excerpt

Accumulating evidence shows that colorectal cancer stem cells (CRSCs) are largely responsible for the metastasis and relapse of colorectal cancer (CRC) after therapy. Hence, identifying new agents that specifically target CRSCs would help improve the effectiveness of current CRC therapies. To accelerate identification of agents targeting CRSCs, the Connectivity Map (CMap) approach was used. Among the top-ranked...

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PMID: 26136074
DOI: 10.1038/cddis.2015.155

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